AGR 2 Function Requires a Unique Endoplasmic Reticulum Localization Motif
نویسندگان
چکیده
Background: Whether AGR2 promotes adenocarcinoma growth as a secreted or ER localized protein is not known. Results: A unique C-terminal motif, KTEL, is required for AGR2 ER localization and function. Conclusions: Not all ER localization motifs are interchangeable. Significance: Specific ER localization signals may be required for protein function. AGR2's tumor promoting effects are mediated from the ER and not as a secreted protein.
منابع مشابه
AGR2 gene function requires a unique endoplasmic reticulum localization motif.
Soluble proteins are enriched in the endoplasmic reticulum (ER) by retrograde transport from the Golgi that is mediated by the KDEL receptors. In addition to the classic carboxyl-terminal KDEL motif, a variety of sequence variants are also capable of receptor binding that result in ER localization. Although different ER localization signals that exhibit varying affinities for the KDEL receptors...
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تاریخ انتشار 2011